NuPathe Drug Delivery Platforms

SmartRelief™ - electronically assisted drug delivery (iontophoresis)

SmartRelief™ iontophoresis is a non-invasive technology that utilizes low-level electrical energy to transport drugs through the skin in a safe and effective manner. The rate and amount of drug delivered is controlled electronically, so that the patient receives consistent therapy each and every time. Iontophoresis is an established drug delivery technology with multiple applications currently being used by physicians.

SmartRelief™ is a breakthrough in iontophoretic patch technology - a thin, self-contained, disposable patch.

Up until now iontophoresis was limited to office-based or chronic applications where cumbersome and costly electronics were acceptable. SmartRelief™ is the next generation of iontophoresis. SmartRelief™ is easy and cost-effective.  Each SmartRelief™ patch is pre-programmed, disposable, and convenient to use.

LAD™ Long-Acting Delivery Technology

Effective long-term therapy of neuropsychiatric conditions requires consistent therapy, including constant, stable drug levels over prolonged periods of time. Unfortunately, patient compliance and drug pharmacokinetics present significant obstacles to consistent therapy. NuPathe is addressing these issues through its proprietary LAD™ long acting delivery technology. LAD™ enables drugs to be delivered with unparalleled control, consistency and convenience for 1-3 months with a single application.

LAD™ consists of a small biodegradable polymer matrix, formed into a small rod, no bigger than a grain of rice. A dose is administered through an injection and resides just below the skin where it slowly degrades over a defined period of time. By reducing dose frequency and variability, medications using the LAD™ technology may provide physicians and patients with an important therapeutic option for the treatment of chronic neurological and psychiatric diseases.